NECESSARY: New patient-specific functional assessment of the anomalous aortic origin of coronary arteries: stratifying the risk for myocardial ischemia and sudden death.
New patient-specific functional assessment of the anomalous aortic origin of coronary arteries: stratifying the risk for myocardial ischemia and sudden death
NECESSARY
Dr. Mauro Lo Rito (Congenital Cardiac Surgery, Radiology Unit, Clinical and Interventional Cardiology, Policlinico San Donato) [PI], Michele Conti (Department of Civil Engineering and Architecture, Univeristy of Pavia) [Operative unit], Dr. Francesco Secchi (Diagnostic Imaging, Policlinico San Donato) [Operative unit], Dr. Mauro Luca Agnifili (Congenital Cardiac Surgery, Radiology Unit, Clinical and Interventional Cardiology, Policlinico San Donato) [Operative unit]
€ 160.000,00
€ 850.300,00
Italian Ministry Of Health
Ricerca Finalizzata 2019 (GR-2019-12369116)
2021 – 2024 (3 years)
Anomalous Aortic Origin of the Coronary Arteries (AAOCA) is a rare congenital disease that may cause sudden death in young and adult subjects. Currently, the decision to perform corrective surgery is based on the morphologic characteristics of the anomalous coronary without the support of a functional evaluation of the vessel. The goal of NECESSARY is to assess the mechanical compression of the anomalous coronary and the consequent impact on coronary blood supply by means of patient-specific computational simulations of the aortic root and coronary tree. The expectation is that a personalized quantitative analysis will allow a better ischemic risk stratification, improving the indication for surgery for these patients.
