MALAN: Mapping of aortic arch hemodynamics by biomechanical analysis and modeling for planning Thoracic Endovascular Aortic Repair (TEVAR)
Mapping of aortic arch hemodynamics by biomechanical analysis and modeling for planning Thoracic Endovascular Aortic Repair (TEVAR)
Dr. M.M. Marrocco-Trischitta (UO1 – Division of Vascular Surgery II, Policlinico San Donato, Milan) [PI], Prof. Ferdinando Auricchio (UO2 – Department of Civil Engineering and Architecture, University of Pavia) [Operative Unit Responsible]
Italian Ministry Of Health
Ricerca Finalizzata 2016 (GR-2018-12368376)
2018 – 2021 (3 years)
Thoracic endovascular aortic repair (TEVAR) for disease involving the aortic arch remains complex and challenging due the angulation and tortuosity of the arch and its peculiar biomechanical environment. Currently, TEVAR planning is based on the analysis of anatomical features by means of static imaging protocols. Such an approach, however, disregards the impact of pulsatile forces that are transmitted as migration forces on the terminal fixation sites of the endograft, and may jeopardize the long-term clinical success of the procedure. Hence, we aim to assess the migration forces acting on different proximal landing zones of the aortic arch by computational modeling, and develop in silico patient-specific simulations that can provide a quantitative evaluation of the stent-graft performance. Our results are expected to provide valuable insights for proper proximal landing zone and stent-graft selection during TEVAR planning, and ultimately improve postoperative outcome.